Wade D, Flock JI, Edlund C, Löfving-Arvholm I, Sällberg M, Bergman T, Silveira A, Unson C, Rollins-Smith L, Silberring J, Richardson M, Kuusela P, Lankinen H. Antibiotic properties of novel synthetic temporin A analogs and a cecropin A-temporin A hybrid peptide. Protein and peptide letters. 2002 Dec;9(9). 533-43. PMID: 12553862 [PubMed]
Temporin A, 18 analogs, and a cecropin A-temporin A hybrid peptide were tested with antibiotic sensitive and resistant bacteria, fungi, human erythrocytes, and in clotting assays. Several peptides were active in these assays, and some analogs (D-TA, W1-TA, and Con-L4,G10) may be useful lead compounds for further antibiotics development. The activity of temporin A was found to be dependent upon several of its structural features, including amino acid composition and sequence, chirality, helicity, and positive charge.